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KMID : 1123920070210030714
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Korean Journal of Oriental Physiology and Pathology
2007 Volume.21 No. 3 p.714 ~ p.720
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Suppression of DNCB-induced Dermatitis in NC/Nga Murine Model by Biheoonsupbang
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Kim Jeong-Hwan
Choi Jeong-June
Koo Young-Sun
Roh Seong-Soo
Kim Dong-Hee
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Abstract
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Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by inflammatory cell infiltration in the skin. This study was performed to assess the therapeutic effects of BHOSB on the DNCB-induced dermatitis in NC/Nga mice, characterized by the onset of AD along with an increase the number of inflammatory cells and dysregulation of inflammatory mediators including cytokines and chemokines. BHOSB administration significantly reduced clinical dermatitis severity including pruritus, edema, eczematous and erythema. Histological findings indicated that the thickening of epidermis/dermis and dermal infiltration of inflammatory cells including mast cells were dramatically reduced. The suppression of dermatitis by BHOSB was accompanied by a decrease in the number of CD11b/Gr-1 immune cells in skin but not CD3/CCR3 cells. However, the number of CD3 cells was increased in BHOSB administrated NC/Nga mice. Oral administration of BHOSB significantly reduced the level of IL-6, TNF-a and eotaxin 2 mRNA in skin. These data suggest that BHOSB may be effective therapeutic agents for the treatment of AD.
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KEYWORD
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Biheoonsupbang, atopic dermatitis, NC/Nga mice, immune modulation, granulocyte, cytokines
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